Leprosy and tuberculosis concomitant infection: a poorly understood, age-old relationship

Historically, archaeological evidence, post-mortem findings and retro- spective analysis of leprosy institutions’ data demonstrates a high observed incidence of concomitant infection with leprosy and tuberculosis (TB). However, reports of concomitant infection in the modern literature remain scarce, with estimates of annual new case detection rates of concomitant infection at approximately 0·02 cases per 100,000 population. Whilst the mechanism for this apparent decline in concomitant infections remains unclear, further research on this topic has remained relatively neglected. Modelling of the interaction of the two organisms has suggested that the apparent decline in observations of concomitant infection may be due to the protective effects of cross immunity, whilst more recently others have questioned whether it is a more harmful relationship, predisposing towards increased host mortality. We review recent evidence, comparing it to previously held understanding on the epidemiological relationship and our own experience of concomitant infection. From this discussion, we highlight several under-investigated areas, which may lead to improvements in the future delivery of leprosy management and services, as well as enhance understanding in other fields of infection management. These include, a) highlighting the need for greater understanding of host immunogenetics involved in concomitant infection, b) whether prolonged courses of high dose steroids pre-dispose to TB infection? and, c) whether there is a risk of rifampicin resistance developing in leprosy patients treated in the face of undiagnosed TB and other infections? Longitudinal work is still required to characterise these temporal relationships further and add to the current paucity of literature on this subject matter

Predicting Item Popularity: Analysing Local Clustering Behaviour of Users

Predicting the popularity of items in rating networks is an interesting but challenging problem. This is especially so when an item has first appeared and has received very few ratings. In this paper, we propose a novel approach to predicting the future popularity of new items in rating networks, defining a new bipartite clustering coefficient to predict the popularity of movies and stories in the MovieLens and Digg networks respectively. We show that the clustering behaviour of the first user who rates a new item gives insight into the future popularity of that item. Our method predicts, with a success rate of over 65% for the MovieLens network and over 50% for the Digg network, the future popularity of an item. This is a major improvement on current results.Comment: 25 pages, 11 figure

Identifying Influential Nodes in Bipartite Networks Using the Clustering Coefficient

The identification of influential nodes in complex network can be very challenging. If the network has a community structure, centrality measures may fail to identify the complete set of influential nodes, as the hubs and other central nodes of the network may lie inside only one community. Here we define a bipartite clustering coefficient that, by taking differently structured clusters into account, can find important nodes across communities

The Impact of Orography and Latent Heating on the Location of the Tropical Easterly Jet

The Tropical Easterly Jet (TEJ) is a prominent atmospheric circulation feature observed during the Asian Summer Monsoon. It is generally assumed that Tibet is an essential ingredient in determining the location of the TEJ. However studies have also suggested the importance of latent heating in determining the jet location. The relative importance of Tibetan orography and latent heating is explored through simulations with a general circulation model. The simulation of TEJ by the Community Atmosphere Model, version 3.1 (CAM-3.1) has been discussed in detail. Although the simulated TEJ replicated many observed features of the jet, the jet maximum was located too far to the west when compared to observation. The precipitation in the control simulation was high to the west of India and this caused the TEJ to shift westwards by approximately the same amount. Orography was found to have minimal impact on the simulated TEJ hence indicating that latent heating is the crucial parameter. The primacy of latent heating in determining the jet location was confirmed by additional simulations where the simulated precipitation was brought closer to observations. This made the TEJ to also shift to the correct position.Comment: 14 pages including 7 figures and 1 tabl

Peristaltic flow of a Newtonian fluid through a porous medium in a vertical tube under the effect of a magnetic field

In this paper, we studied the effects of heat transfer and magnetic field with peristaltic flow of a viscous incompressible Newtonian fluid through a porous medium in a vertical tube under the assumptions of long wavelength and low Reynolds number. The closed form solutions of velocity field and temperature are obtained. The influence of various pertinent parameters on the flow characteristics, the temperature and the heat transfer coefficient are discussed through graphs

Prediction Weighted Maximum Frequency Selection

Shrinkage estimators that possess the ability to produce sparse solutions have become increasingly important to the analysis of today's complex datasets. Examples include the LASSO, the Elastic-Net and their adaptive counterparts. Estimation of penalty parameters still presents difficulties however. While variable selection consistent procedures have been developed, their finite sample performance can often be less than satisfactory. We develop a new strategy for variable selection using the adaptive LASSO and adaptive Elastic-Net estimators with $p_n$ diverging. The basic idea first involves using the trace paths of their LARS solutions to bootstrap estimates of maximum frequency (MF) models conditioned on dimension. Conditioning on dimension effectively mitigates overfitting, however to deal with underfitting, these MFs are then prediction-weighted, and it is shown that not only can consistent model selection be achieved, but that attractive convergence rates can as well, leading to excellent finite sample performance. Detailed numerical studies are carried out on both simulated and real datasets. Extensions to the class of generalized linear models are also detailed.Comment: This manuscript contains 41 pages and 14 figure

Dublin City University at CLEF 2006: Experiments for the ImageCLEF Photo Collection Standard Ad Hoc Task

We provide a technical description of our submission to the CLEF 2006 Cross Language Image Retrieval(ImageCLEF) Photo Collection Standard Ad Hoc task. We performed monolingual and cross language retrieval of photo images using photo annotations with and without feedback, and also a combined visual and text retrieval approach. Topics are translated into English using the Babelfish online machine translation system. Our text runs used the BM25 algorithm, while our visual approach used simple low-level features with matching based on the Jeffrey Divergence measure. Our results consistently indicate that the fusion of text and visual features is best for this task, and that performing feedback for text consistently improves on the baseline non-feedback BM25 text runs for all language pairs

Mitochondrial Molecular Adaptations and Life History Strategies Coevolve in Plants

Messenger RNA secondary structure prevents mutations at functionally important sites. Mutations at exposed sites would cause micro-adaptations, niche-specialization, and therefore, can be thought to promote K-strategists. Exposing, rather than protecting, conserved sites, is also potentially adaptive because they probably promote macro-adaptive changes. This presumably fits r-strategists: their population dynamics tolerate decreased survival. We found that helix-forming tendencies are greater at evolutionary conserved sites of plant mitochondrial mRNAs than at evolutionary variable sites in a majority (73%) of species–gene combinations. K-strategists preferentially protect conserved sites in short genes, r-strategists protect them most in larger genes. This adaptive scenario resembles our earlier findings in chloroplast genes. Protection levels at various codon positions also display disparity with respect to life history strategies of the plants. Conserved site protection increases overall mRNA folding stabilities for some genes, while decreases it for some others. This contrast exists between homologous genes of r- and K- strategists. Such compensating interactions between variability, mRNA size, codon position, and secondary structure factors within r- and K-strategists are most likely, molecular adaptations of plants belonging to the two extreme life history strategies. Our results suggest coevolution between molecular and ecological adaptive strategies

Tectonic evolution of greenstone-Gneiss association in Dharwar Craton, South India: Problems and perspectives for future research

The two fold stratigraphic subdivision of the Archean-Proterozoic greenstone-gneiss association of Dharwar craton into an older Sargur group (older than 2.9 Ga.) and a younger Dharwar Supergroup serves as an a priori stratigraphic model. The concordant greenstone (schist)-gneiss (Peninsular gneiss) relationships, ambiguities in stratigraphic correlations of the schist belts assigned to Sargur group and difficulties in deciphering the older gneiss units can be best appreciated if the Sargur group be regarded as a trimodal association of: (1) ultrabasic-mafic metavolcanics (including komatiites), (2) clastic and nonclastic metasediments and paragneisses and (3) mainly tonalite/trondhemite gneisses and migmatites of diverse ages which could be as old as c. 3.4 ga. or even older. The extensive occurrence of this greenstone-gneiss complex is evident from recent mapping in many areas of central and southern Karnataka State